Restoring a Competent Permeability Barrier

Animal studies suggest that increased water loss is a trigger for skin barrier repair.¹

EpiCeram complements the metabolic responses that allow skin barrier repair in atopic dermatitis. In a study of in an animal model with atopic dermatitis, of various barrier repair therapies (i.e. EpiCeram, Atopiclair® and MimyX®), only EpiCeram treatment improved transdermal water loss (TEWL) relative to control.

Atopic Skin Treated with EpiCeram Display accelerated Recovery of Barrier Function

In this study, multiple sites on oxazolone-treated mice were tape stripped until TEWL levels were five times greater than or equal to baseline. A small amount of EpiCeram was applied to 18 sites. Recovery was then measured as a change in TEWL.²

1. Grubauer G, et al. J Lipid Res 1989;30:323-333.