Normalizing the pH of the Stratus Corneum

Inflammation inevitably leads to an increase in the pH of the stratum corneum. Moreover, decreased filaggrin expression in atopic dermatitis aggravates this increase in pH. The increase in pH adversely affects barrier function by raising serine protease activity in the stratum corneum.1

EpiCeram has free fatty acids and a buffer that reduce the product's overall pH level to normal physiologic levels.2 When EpiCeram is applied to the skin, it normalizes the overall pH of the stratum corneum. As a consequence, serine protease activity within the stratum corneum is also normalized.

1. Elias PM. Arch Dermatol 2003;139(11):1417-22. 2. Data on File. Bridgewater, NJ: Promius Pharma, UC; 2008.

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