Providing Bulk Replenishment of Physiologic Lipids

Normalization of skin barrier function by EpiCeram is due to restoration of the normal content of physiological lipids in the stratum corneum.

In normal patients, lipids account for 10% of the weight of the stratum corneum. However, patients with atopic dermatitis have a reduction in total stratum corneum lipids, even in nonlesional skin.1 To correct this deficiency, EpiCeram replenishes the stratum corneum with physiologic lipids that incorporate into the epidermis and stratum corneum.

EpiCeram replenishes the epidermis with physiologic lipids, including high concentrations of ceramides, cholesterol and free fatty acids.2 Ceramides and physiologic lipids penetrate through the stratum corneum and into the stratum granulosum where they are processed, complementing lipids produced by the epidermis. The lipids in EpiCeram are then incorporated into the stratum corneum where they form lamellar bilayers.3,4

Incorporation of physiologic lipids into the stratum corneum3

1. Imokawa G, et al. J Invest Dermatol 1991;96:523-6. 2. Data on File. Bridgewater, NJ: Promius Pharma, UC; 2008. 3. Mao-Qiang M, et al. Arch Dermatol 1995;131:809-816. 4. Bikowski et al. Practical dermatology. May 2009: pg 17-18

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