Hypothesis About Where the Disease Starts

There are currently two alternate hypotheses to explain where the disease starts.

According to the "inside-out" hypothesis, atopic dermatitis starts inside the skin, with an immune system that is especially prone to inflammation.

According to the "outside-in" theory, atopic dermatitis starts because the skin barrier is defective (it is poor in the essential fats that make the skin soft and thick: ceramides, cholesterol and free fatty acids). This weak skin barrier lets in all kinds of irritants that would be kept out by normal skin.

Home     |     About Atopic Dermatitis     |     Who is affected     |     Treating Atopic Dermatitis     |     What is Epiceram?     |     Q&A     |     Contact Us     |     Site Map